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Oligonucleotide-based therapeutics targeting COVID-19

Background Oligonucleotides (ONs) are a promising class of agents in the fight against a wide variety of diseases including cancers, neuropathies, and metabolic disorders. Despite decades of research results indicating widespread clinical success, the therapeutic use of ONs have yet to be realized, which is somewhat due to the bio-pharmaceutical difficulties...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Ke Zhang

Keywords(s): COVID

Category(s): -Sensors, Technology Classifications > 1. Life Science > Therapeutics

Making Oligonucleotides Better Biopharmaceuticals with Brush Polymer-Assisted Compaction

INV-16006 Background Oligonucleotide-based gene therapy holds tremendous promise for treating a variety of disorders with a genetic basis, including cancers, neurological diseases, and metabolic conditions. However, due to difficulties including poor accumulation at target sites, removal by immune responses, nuclease degradation, and low biochemical...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Ke Zhang, Xueguang Lu

Keywords(s):

Category(s): -Cancer, -Chemistry, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Delivery