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Site-specific Modification of Antibody through a Tranglutaminase-mediated Conjugation of Glutamine While Maintaining the Core Glycan

Site-specific Modification of Antibody through a Transglutaminase-mediated Conjugation of Glutamine While Maintaining the Core Glycan Technical advancement of site-specific antibody engineering creating more homogenous biologics Institute Reference: INV-21035 Background Antibodies are a predominant class of macromolecules with wide-spread...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Zhaohui Zhou, Amissi Sadiki

Keywords(s): Antibody conjugates, Endoglycosidase, Glycan remodeling, Glycoengineering, Transglutaminase

Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Biotechnology, Diagnostics

Chemo-Enzymatic Site-Specific Photocaging of Peptides and Proteins

INV-17072 Background Photocaging is a process in which a molecule is covalently modified by a photolabile group; the molecule is often referred to as being ‘caged.’ Typically. caging renders the molecule non-functional. Subsequently, photolysis of such ‘caged’ peptides and proteins removes the photolabile group and regenerates...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Zhaohui Zhou, Kevin Moulton, Shanshan Liu

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering