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Nanopore and membrane protein dynamic multichannel measurement apparatus and fabrication method for same

INV-23089 Background: Nanopore sensing devices are integral to scientific research and applications such as DNA sequencing and protein detection. The dynamic of trans and cis user access to a membrane in such devices can, however, pose significant challenges. Fulfilling the need for multiplexed and scalable nanopore sensing systems, especially those...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Meni Wanunu, Ali Fallahi, Amr Makhamreh

Keywords(s): Biosensing, Drug Discovery, Microfluidics, Nanopores, Protein sequencing

Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 2. Physical Science, Technology Classifications > 1. Life Science > Gene sequencing, Diagnostics

New Method for Discovery of Bioactive Molecules

INV-20024 Background Microbes are a foundation of the discovery of bioactive molecules because they produce an enormous variety of secondary metabolites, some with desirable activities ranging from antibiotics to anti-inflammatory to anticancer to industrial enzymes. The advent of next-generation sequencing technologies uncovered that microbial genomes...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Slava Epstein

Keywords(s): Antimicrobial, Biomolecules, Cancer, Drugs, Microbiology

Category(s): -Method, Technology Classifications > 1. Life Science > Drug Discovery, Antimicrobial, Technology Classifications > 1. Life Science > Gene sequencing

Electrically Actuatable Zero-mode Waveguides for High-Throughput pg-Level Sequencing

INV-20008 Background DNA sequencing technologies have undergone tremendous improvements in recent years in throughput and quality. One advantage of single-molecule DNA sequencing technologies is that long DNA molecules can be read in a single run, which greatly facilitates genome assembly and aids in the construction of reference-quality genomes....

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Meni Wanunu, Mohammadamin Alibakhshi, Fatemeh Farhangdoust

Keywords(s): DNA sequencing, single-molecule

Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Gene sequencing, Chemistry