Search Results - cancer

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A wide-field system integrating intensity- and spatially- modulated light for diffuse optical tomography and spectroscopy applications

INV-22102 Background Diffuse optical tomography (DOT) is a non-invasive optical imaging technique that is capable of imaging deep (>1 cm) tissue physiology, such as angiogenesis and metabolism, using only non-ionizing near-infrared light. When modulating the DOT light source intensity at a radio-frequency (RF), a frequency-domain DOT (FD-DOT) can...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Qianqian Fang, Miguel Mireles Nunez, Edward Xu

Keywords(s): Cancer, Diffuse Optical Tomography, Spatial Frequency Domain Imaging (SFDI), Speckle Contrast Optical Spectroscopy (SCOS), Speckle Contrast Optical Tomography (SCOT), Wide-field

Category(s): Technology Classifications > 1. Life Science

DNA Adductomics by Mass Tag Prelabeling

Background DNA adducts are damaged nucleotides in DNA as a consequence of its exposure to genotoxic agents or conditions. Measurement of multiple DNA adducts in a single procedure is referred to as “DNA adductomics”. In the leading analytical technique for this purpose, typically the following sequence of steps takes place starting with...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Roger Giese, Poguang Wang

Keywords(s): Cancer, cancer prevention, DNA adduct, Mass Spectrometry, Mass tags, personalized medicine

Category(s): -Cancer

New Method for Discovery of Bioactive Molecules

INV-20024 Background Microbes are a foundation of the discovery of bioactive molecules because they produce an enormous variety of secondary metabolites, some with desirable activities ranging from antibiotics to anti-inflammatory to anticancer to industrial enzymes. The advent of next-generation sequencing technologies uncovered that microbial genomes...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Slava Epstein

Keywords(s): Antimicrobial, Biomolecules, Cancer, Drugs, Microbiology

Category(s): -Method, Technology Classifications > 1. Life Science > Drug Discovery, Antimicrobial, Technology Classifications > 1. Life Science > Gene sequencing

Single-cell Pairing Chip for Personalized Immunotherapeutic Screening

INV-19067 Background Natural Killer cells are a type of white blood cell that physically interact with target cancer cells and determine whether to lyse them. The innate heterogeneity of both cancer and NK cells leads to a variety of interactions between pairs of NK-cancer cells. Therefore, single-cell analysis would help in analyzing these interactions...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Yantao Fan, Tania Konry

Keywords(s): Biotech, Cancer

Category(s): -Cancer, -Biology, -Devices, Technology Classifications > 1. Life Science, Diagnostics, Technology Classifications > 1. Life Science > Drug Discovery, Chemistry

Radionuclidic and Non-radionuclidic Molecular Imaging Agents for the Estrogen Receptor Based on 11-beta Subsituted Steroidal Anti-Estrogens

INV-13041 Background Breast cancer has become the most common cancer globally as of 2021, accounting for 12% of all new annual cancer cases worldwide, according to the World Health Organization. Among patients with breast cancer, approximately 75% have elevated expression of estrogen receptor (ER). Knowing the hormone receptor status of cancer is...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Robert Hanson, Kinh-Luan (Lenny) Dao

Keywords(s): Cancer, Chemistry, Diagnostics, Health, Medical imaging, Medical/Health, Science/Research

Category(s): -Health, Technology Classifications > 3. Computer Science > Imaging, Diagnostics, Technology Classifications > 1. Life Science > Theragnostic

Macrophage-Targeted Multi-Compartmental Delivery Systems

INV-1028 Background Macrophages are important immune cells in the body that regulate different biological processes involved in inflammatory and infectious diseases. Macrophages originate from the mononuclear phagocyte system (MPS) in the bone marrow. The MPS system comprises of monocytes and tissue, it matures into a larger phagocytic cell called...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Mansoor Amiji, Husain Attarwala, Shardool Jain, Mayur Kalariya

Keywords(s): Biotech, Breast Cancer, Cancer, Chemotherapy, Drug Delivery, Drugs, Health, Medical, Nanomedicine

Category(s): -Biomedical Materials, -Nanomedicine, -Cancer, -Health, Technology Classifications > 1. Life Science > Drug Delivery

Man 1-2 Man-PEGylated Derivative as a Tool for in vitro and in vivo Dendritic Cell Targeting

INV-1151 Background The immune system (IS) has a delicate equilibrium between its cells. The most important cells of the IS are the B lymphocytes (BL), macrophages (MO), and dendritic cells (DC), so-called antigen presenting cells (APC). They are the key-linkers between the innate and the adaptive immunity, which is a crucial factor that will lead...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Vladimir Torchilin, Tatiana Levchenko, Juan Pappalardo, Stefano Salmaso, Micaela Toniutti

Keywords(s): Cancer, Chemistry, COVID, Drug Delivery, Genome, Health, Healthcare Innovation, Medical, Nanomedicine, Research Tool

Category(s): -Nanomedicine, -Cancer, -Health, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Therapeutics

Allosteric Modulators of CB1 Cannabinoid Receptors

style-name: Hyperlink;color: #0000FF;text-decoration: underline; } INV-1242 Background Anorexia nervosa (AN) is a major psychiatric eating disorder associated with substantial morbidity and mortality. Its characteristic symptoms include the refusal to maintain minimally normal body weight, an intense fear of becoming fat, and a disturbed perception...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Ganeshsingh Thakur, Pushkar Kulkarni

Keywords(s): Cancer, Chemistry, Drug Discovery & Development, Drugs, Therapeutic

Category(s): -Chemistry, -Pharmaceutical Composition, -Health, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Therapeutics