Search Results - technology+classifications+%3e+1.+life+science+%3e+drug+discovery

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GlycoFix-3 (Structurally and Functionally Repaired Endothelial Glycocalyx, 3rd Edition)
GlycoFix-2 is a chemical formulation that repairs blood vessel linings to prevent heart diseasesGlycoFix-2: Chemical Repair of Blood Vessel Linings for Heart Disease PreventionBackground The endothelial glycocalyx is a sugar mesh coat that serves as a protective barrier for endothelial cells, such as blood vessels. The endothelial glycocalyx can...
Published: 1/27/2025   |   Updated: 1/24/2025   |   Inventor(s): Eno Ebong, Solomon Mensah, Ronodeep Mitra
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering
Depleting oxygen in the gut
This invention uses membrane vesicles from bacteria to deplete oxygen in the gut, preventing the growth of harmful bacteria and improving colon health, particularly in conditions like colitis. https://nu.technologypublisher.com/files/sites/adobestock_801639063.jpeg https://nu.technologypublisher.com/files/sites/vaibhav-1280x1600.jpeg Source:...
Published: 1/27/2025   |   Updated: 9/25/2024   |   Inventor(s): Kim Lewis, Norman Pitt, Madeleine Morrissette
Keywords(s): Healthcare Innovation, Microbiology
Category(s): -Health, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Therapeutics
Neuro-Behavioral Assay for Physiological Evaluation of Water-Soluble Anesthetics
Background The development and use of general anesthetics is a key aspect of modern medicine. However, the current reliance on lipid-soluble general anesthetics presents issues, particularly for elderly patients who often have increased adipose tissue and decreased body water. This demographic can respond poorly to lipid-soluble anesthetics, resulting...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Gunther Zupanc, David Lehotzky
Keywords(s): Anesthesiology, Assays, Chemotherapy, Drug Discovery & Development, High Throughput Screening
Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Drug Discovery
New Method for Discovery of Bioactive Molecules
INV-20024 Background Microbes are a foundation of the discovery of bioactive molecules because they produce an enormous variety of secondary metabolites, some with desirable activities ranging from antibiotics to anti-inflammatory to anticancer to industrial enzymes. The advent of next-generation sequencing technologies uncovered that microbial genomes...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Slava Epstein
Keywords(s): Antimicrobial, Biomolecules, Cancer, Drugs, Microbiology
Category(s): -Method, Technology Classifications > 1. Life Science > Drug Discovery, Antimicrobial, Technology Classifications > 1. Life Science > Gene sequencing
Transwell Millifluidic
INV-19073 Background Many common microfluidic devices experience issues with cell seeding due to their small dimensions and need to be seeded using perfusion. Similarly, the diffusion of nutrients, including oxygen, is limited in many common microfluidics also due to small dimensions. Additionally, while immunofluorescence is the main analytical assay...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Eno Ebong, Ian Harding, Ira Herman, Abigail Koppes, Alex Caraballo
Keywords(s): Biotech, Cardiovascular, Devices
Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 1. Life Science, Technology Classifications > 2. Physical Science > Lab tech/equipment, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Drug Discovery
Consistent and enhanced production of anti-cancer drugs from the Madagascar periwinkle plant
INV-19070 Background The Madagascar periwinkle plant has been used for vinblastine (VBL) and vincristine (VCR) since the 1960s. These chemical compounds have been listed on “World Health Organization’s Model List of Essential Medicines”. However, due to high cost, low concentration in extracts, and unpredictable supply, the applications...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Carolyn Lee-Parsons, Elisa Peter, Samuel Mortensen
Keywords(s): Agriculture/Horticulture, Chemotherapy, Manufacturing, Process, Renewable
Category(s): Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Green Chemistry, Chemistry
Single-cell Pairing Chip for Personalized Immunotherapeutic Screening
INV-19067 Background Natural Killer cells are a type of white blood cell that physically interact with target cancer cells and determine whether to lyse them. The innate heterogeneity of both cancer and NK cells leads to a variety of interactions between pairs of NK-cancer cells. Therefore, single-cell analysis would help in analyzing these interactions...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Yantao Fan, Tania Konry
Keywords(s): Biotech, Cancer
Category(s): -Cancer, -Biology, -Devices, Technology Classifications > 1. Life Science, Diagnostics, Technology Classifications > 1. Life Science > Drug Discovery, Chemistry
High throughput toxicity assay on coordinately ordered single cells with individual identity
INV-18104 Background Cytotoxicity plays an important role in understanding biological mechanisms, detecting diseases, and screening therapeutics. Cytotoxicity measurement is usually carried out by incubating cells in different sized wells with a specific treatment, which yields results based on the average response of cells in the same well. However,...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Ming Su, Qingxuan Li, Liyuan Ma
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery
A Minimal Cell Lysis and Bottom-up Proteomics Sample Preparation Technique
INV-18031 Background Quantifying proteins in limited samples are required for many practical applications, including biopsies, tissue samples, clinical trial of pharmaceuticals, and others. Several methods have been developed for doing sample prep with minimal losses. However, all existing methods uses a chemical that undermines mass-spec analysis...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Nikolai Slavov, Bogdan Budnik, Harrison Specht
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Drug Discovery, Diagnostics, Chemistry
Ultrasensitive and High-Throughput Quantification of Post-translational Modifications of Proteins by Mass Spectrometry
INV-18021 Background Advances in single-cell RNA-sequencing (transcriptomics) and genomics have been instrumental in our understanding of gene expression and human disease. While advancements have been made in single-cell protein analysis, state of the art technologies still have significant limitations. Most proteomic methods rely on antibodies...
Published: 1/27/2025   |   Updated: 3/21/2024   |   Inventor(s): Nikolai Slavov, Bogdan Budnik, Ezra Levy
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science > Drug Discovery
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