Search Results - therapeutic

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Biodegradable Implant for Sustained Trans-Nasal Delivery to the Brain

A sustained-release delivery vehicle for the treatment of brain diseases https://nu.technologypublisher.com/files/sites/1-s2.0-s0168365921000365-ga1_lrg.jpg Source: mrithi Padmakumar, Gregory Jones, Grishma Pawar, Olga Khorkova, Jane Hsiao, Jonghan Kim, Mansoor M. Amiji, Benjamin S. Bleier, Minimally Invasive Nasal Depot (MIND) technique...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Mansoor Amiji, Smrithi Padmakumar, Benjamin Bleier

Keywords(s): Biomedical implants, Neurological Disease, Pharmaceutical Composition, Therapeutic

Category(s): -Materials, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering

Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies

INV-20012 Background Nanobodies, are a novel class of therapeutic proteins based on single-domain antibody fragments. Due to their small size and unique structure, they have shown great potential as next generation biological drugs. Existing methods for producing these nanobodies have come with certain drawbacks. A common method for production...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Jiahe Li

Keywords(s): Antibody manufacturing, Drugs, Protein production, Therapeutic

Category(s): -Nanomedicine

Nanococktail for combination therapy, compositions, methods, and uses

INV-20007 Background It is difficult to achieve optimal exposure of all agents in combination therapy with drugs that exhibit different properties. Nanoparticle delivery systems are a well-known means to modify the pharmacokinetics and distribution of drugs. Northeastern researchers have demonstrated that through nanoencapsulation, similar pharmacokinetic...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Srinivas Sridhar, Paige Baldwin, Bijay Singh

Keywords(s): Combination therapy, Drug Delivery, Nanomedicine, Therapeutic, Treatment

Category(s): -Nanotechnology, -Materials

Robotic Leg Advancement Device

Robotic Leg Advancement Device A novel robotic device for automation of a physical therapy for gait patients Institute Reference: INV-14007 Background A commonly used gait training paradigm relies on manual leg advancement, where the Physical Therapists (PTs) help patients take their legs through the proper motion during ambulation over a treadmill,...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Maciej Pietrusinski, Constantinos Mavroidis (Bei)

Keywords(s): Medical Device, Robotics, Therapeutic

Category(s): Technology Classifications > 1. Life Science > Medical Devices

Method for Delivery to the Brain of Plasmid DNA Encoding Therapeutic Proteins for CNS Disorders

#0000FF;text-decoration: underline;border-collapse: collapse; } INV-1262 Background Neurodegenerative diseases are debilitating diseases that impose significant financial and social impact and burden. The prevalence of these diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, is progressing...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Barbara Waszczak, Brendan Harmon, Mark Cooper

Keywords(s): Biology, Biotech, Chemistry, Drug Delivery, Health, Medical, Medical/Health, Method, Neurological Disease, Process, Psychiatric Disease, Therapeutic

Category(s): -Biology, -Health, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Therapeutics

Allosteric Modulators of CB1 Cannabinoid Receptors

style-name: Hyperlink;color: #0000FF;text-decoration: underline; } INV-1242 Background Anorexia nervosa (AN) is a major psychiatric eating disorder associated with substantial morbidity and mortality. Its characteristic symptoms include the refusal to maintain minimally normal body weight, an intense fear of becoming fat, and a disturbed perception...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Ganeshsingh Thakur, Pushkar Kulkarni

Keywords(s): Cancer, Chemistry, Drug Discovery & Development, Drugs, Therapeutic

Category(s): -Chemistry, -Pharmaceutical Composition, -Health, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Therapeutics

Nanopreparation for Co-Delivery of Drugs and siRNA

INV-13004 Background Overexpression of p‑glycoprotein (encoded by MDR1 gene) is often associated with multidrug-resistant cancer. This protein leads to drug resistance by the efflux of chemotherapeutic drugs from the cancerous cells. Small interfering RNA (siRNA), also known as post-transcriptional gene silencer, can suppress the expression of specific...

Published: 1/27/2025 | Updated: 3/21/2024 | Inventor(s): Vladimir Torchilin, Swati Biswas

Keywords(s): Delivery, Drug Delivery, Healthcare Innovation, Medical, Nanomedicine, Nanotechnology, Pharmaceutical Composition, Therapeutic

Category(s): -Nanotechnology, -Nanomedicine, -Pharmaceutical Composition, -Health, Technology Classifications > 1. Life Science > Drug Delivery, Technology Classifications > 1. Life Science > Therapeutics